Pediatric Cancer Predisposition Clinic

我的孩子得了癌症. Why might they be seen in the Pediatric Cancer Predisposition Clinic?

At the Pediatric Cancer Predisposition Clinic, we specialize in the diagnosis and management of children and young adults with inherited cancer predisposition syndromes (CPS). Children with a CPS have an increased risk for developing certain cancers. 关于 10%–15% of all pediatric cancers are related to cancer predisposition syndrome. 关于 50% of these patients do not have a family history of cancer. A CPS diagnosis can influence a patient’s cancer prevention, surveillance and treatment. In addition, this information may be important to relatives.

At the Pediatric Cancer Predisposition Clinic, we see patients who have a wide range of cancerous and noncancerous tumors, 包括, 但不限于:

肾上腺皮质癌
Atypical teratoid rhabdoid tumor (ATRT) and malignant rhabdoid tumors (MRT)
Brain cancer (包括 high grade glioma, subependymal giant cell astrocytoma (SEGA), 脉络膜丛癌, 脑膜瘤, 成神经管细胞瘤)
心脏横纹肌瘤
囊性肾瘤
Gastrointestinal stromal tumor (GIST)
Gonadoblastoma
肝母细胞癌
Kidney cancer (包括 Wilms tumor)
Leukemias (包括 hypodiploid pre-B ALL, AML, JMML, and myelodysplastic syndrome)
Multi-nodular甲状腺肿
粘液瘤
骨肉瘤
Ovarian cancer (包括 small cell carcinoma of the ovary, stromal tumors and Sertoli-Leydig cell tumor)
胰腺癌
嗜铬细胞瘤/副神经节瘤
甲状旁腺癌
垂体胚细胞瘤
Pleuropulmonary胚细胞瘤
视网膜成血管细胞瘤
横纹肌肉瘤
视网膜母细胞瘤/ pineoblastoma
肉瘤
Skin cancer (melanoma, squamous cell carcinoma, basal cell carcinoma)
Testicular cancer (包括 large cell calcifying Sertoli-Leydig cell tumor)
甲状腺癌
尿路上皮细胞癌

In the Pediatric Cancer Predisposition Clinic, we see patients with pediatric cancer along with other health issues and/or a family history of cancer, 包括:

不止一种癌症
鲜明的面部特征
Developmental delays, atypical behaviors, learning problems or intellectual disability
Abnormal growth (large/small head, very large or small size, asymmetric growth)
Birth defects (such as cleft palate, 心脏缺陷, 不正常的听力和视力, 胎记或血管病变)
Abnormal blood counts and/or immune system issues
Tumor testing suggestive of an inherited defect
Family history of the same or related cancers

We also see patients with these specific cancer predisposition syndromes that include pediatric-onset cancers:

Birt-Hogg-Dube综合症
卡尼复杂
Constitutional mismatch repair deficiency syndrome
Diamond-Blackfan贫血
DICER1综合症
Fanconi贫血
Hereditary leukemia (包括 inherited bone marrow failure disorders)
遗传性黑素瘤
遗传性神经母细胞瘤
Hereditary paraganglioma-pheochromocytoma syndrome
遗传性视网膜母细胞瘤
Li-Fraumeni综合症
多发性内分泌瘤
Nevoid basal cell carcinoma syndrome (Gorlin syndrome)
Rhabdoid tumor predisposition syndrome
Shwachman-Diamond综合症
结节性硬化症
希佩尔-林道综合征
WT1-Related Wilms tumor syndromes

全球十大外围足球平台

If you believe your child’s personal or family history of cancer is concerning, or if you would like to learn more about genetic counseling and testing in general, ask your oncology team about making a referral for genetic counseling. 您可以直接与我们联系 410-955-3071.

我们的团队

我们的团队 consists of geneticists and genetic counselors who have expertise in pediatric cancer predisposition syndromes, as well as a clinic coordinator. To ensure timely and accurate diagnosis, we work to have patients scheduled as soon as possible. 我们与…密切合作小儿肿瘤小组; when patients need inpatient hospital care, we may consult with the oncology teams who are managing their care.